2016.08 - 2021.10   斯克利普斯研究所，化学系，博士，导师：Prof. Matthew Disney

2012.09 - 2016.06   南京大学，太阳成集团tyc122cc，学士，导师：张艳 教授

2025.04－至今         我校，太阳成集团tyc122cc，长聘教轨副教授，博士生导师

2021.11 - 2024.12   麻省理工学院，化学系，博士后，导师：Prof. Bradley Pentelute

主要研究方向：

1）RNA小分子配体筛选技术开发及平台构建；

2）RNA靶向降解小分子药物的设计与生物应用；

3）RNA体内可视化工具的开发及应用。

2024    国家海外高层次引进人才计划

2024    上海市海外高层次人才引进计划

9. P Zhang, X Ye, JCK Wang, HT Baddock, Z Jensvold, IT Foe, A Loas, DL Eaton, Q Hao, AH Nile*, BL Pentelute*. “Reversibly reactive affinity selection–mass spectrometry enables identification of covalent peptide binders” J. Am. Chem. Soc. 2024, 146(22), 15627—15639. 

8. P Zhang, X Ye, JCK Wang, CL Smith, S Sousa, A Loas, DL Eaton, MP López*, BL Pentelute*. “Development of an α-Klotho recognizing high-affinity peptide probe from in-solution enrichment” JACS Au, 2024, 4, 1334—1344.

7. Y Tong (#), P Zhang (#), X Yang, X Liu, J Zhang, M Grudniewska, I Jung, D Abegg, J Liu, JL Childs-Disney, QMR Gibaut, HS Haniff, A Adibekian, MM Mouradian, MD Disney*. “Decreasing the intrinsically disordered protein α-synuclein by targeting its structured mRNA with a ribonuclease targeting chimera” Proc. Natl. Acad. Sci. U.S.A. 2024, 121 (2), e2306682120.

6. X Ye (#), P Zhang (#), J Tao, JCK Wang, A Mafi, NM Grob, AJ Quartararo, HT Baddock, I Foe, A Loas, DL Eaton, Q Hao, AH Nile*, BL Pentelute*. “Discovery of reactive peptide inhibitors of human papillomavirus oncoprotein E6” Chem. Sci. 2023, 14, 12484—12497.

5. P Zhang, JA Bush, JL Childs-Disney, MD Disney*. “Targeting RNA with small molecules” Handbook of Chemical Biology of Nucleic Acids. Springer, Singapore. 2023.

4. X Ye (#), P Zhang (#), JCK Wang, CL Smith, S Sousa, A Loas, DL Eaton, MP López*, BL Pentelute*. “Branched multimeric peptides as affinity reagents for detection of α-klotho protein” Angew. Chemie Int. Ed. 2023, 62(19), e202300289.

3. P Zhang (#), X Liu (#), D Abegg, T Tanaka, Y Tong, RI Benhamou, JT Baisden, G Crynen, SM Meyer, DM Cameron, AK Chatterjee, A Adibekian, JL Childs-Disney, MD Disney*. “Reprogramming of protein-targeted small molecule medicines to RNA by ribonuclease recruitment” J. Am. Chem. Soc. 2021, 143(33), 13044—13055.

2. JL Chen (#), P Zhang (#), M Abe, H Aikawa, L Zhang, AJ Frank, T Zembryski, C Hubbs, HJ Park, J Withka, C Steppan, L Rogers, S Cabrai, M Pettersson, TT Wager, MA Fountain, G Rumbaugh, JL Childs-Disney, MD Disney*. “Design, optimization, and study of small molecules that target tau pre-mRNA and affect splicing” J. Am. Chem. Soc. 2020, 142(19), 8706—8727.

1. P Zhang, HJ Park, J Zhang, E Junn, RJ Andrews, SP Velagapudi, D Abegg, K Vishnu, MG Costales, JL Childs-Disney, A Adibekian, WM Moss, MM Mouradian*, MD Disney*. “Translation of the intrinsically disordered protein α-synuclein is inhibited by a small molecule targeting its structured mRNA” Proc. Natl. Acad. Sci. U.S.A. 2020, 117(3), 1457—1467.

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